C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/293.1, 260/3
C07D 295/112 (2006.01)
Patent
CA 1058172
ABSTRACT OF THE DISCLOSURE A process is provided for preparing compounds of the general formula (I) Image (I) wherein R1 and R2, when taken separately, stand for saturated alkyl containing 1 to 8 carbon atoms; phenalkyl wherein the alkyl groups contains 1 to 4 carbon atoms; cyclohexyl; or phenyl; and R1 and R2 together with the adjacent nitrogen atoms stand for: piperidino, pyrrolidino; heptamethyleneimino; morpholino; or N-methyl- piperazino; but if R1 stands for methyl, then R2 may only stand for a group other than methyl. The process involves reacting a compound of the general formula (II), Image (II) wherein X stands for halogen, with a secondary amine of the general formula (III), R1 - NH- R2 (III) wherein R1 and R2 each have the same meanings as defined above. The new compounds of the general formula (I), as well as their pharmaceutical1y acceptable acid addition salts ar quaternary ammonium salts not only are active primarily in the induction of liver microsomal enzyme, but also possess antipyretic activity.
205477
Gorog Sandoe
Meszaros Csilla
Palosi Eva
Szeberenyi Szabolcs
Szporny Laszlo
Na
Richter Gedeon Vegyeszeti Gyar Rt
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