C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/08 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) C07D 207/09 (2006.01) C07D 211/20 (2006.01) C07D 333/16 (2006.01) C07D 333/20 (2006.01) C07D 333/32 (2006.01) C07D 335/02 (2006.01)
Patent
CA 2356841
The present invention provides new methods for preparation of various compounds that comprise alicyclic groups with nitrogen or sulfur as ring members, including 2,5-disubstituted tetrahydrothiophenes, 2,5-disubstituted pyrrolidines, 2,6-disubstituted thianes, 2,6-disubstituted hexahydropyridines, 2,7-disubstituted thiepanes, 2,7-disubstituted hexahydroazepines, 2,8- disubstituted thiocanes and 2,8-disubstituted octahydroazocines. The invention further provides novel compounds and pharmaceutical compositions and therapeutic methods that comprise such compounds and compositions.
L'invention concerne de nouvelles méthodes de préparation de différents composés qui comprennent des groupes alicycliques ayant l'azote et le soufre comme éléments du noyau. Ces composés comprennent des tétrahydrothiophènes 2,5-disubstituées, des pyrrolidines 2,5-disubstituées, des thianes 2,6-disubstituées, des hexahydropyridines 2,6-disubstituées, des thiépanes 2,7-disubstituées, des hexahydroazépines 2,7-disubstituées, des thiocanes 2,8-disubstituées et des octahydroazocines 2,8-disubstituées. L'invention concerne également de nouveaux composés, des compositions pharmaceutiques ainsi que des méthodes thérapeutiques qui comprennent ces composés et compositions.
Adhikari Susanta Sekhar
Chorghade Mukund Shankar
Gurjar Mukund Keshao
Krishna Radha Palakodety
Lalitha Sista Venkata Sai
Millennium Pharmaceuticals Inc.
Ridout & Maybee Llp
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