Substituted nitrogen containing heterocycles as inhibitors...

Details Substituted nitrogen containing heterocycles as inhibitors... Substituted nitrogen containing heterocycles as inhibitors...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/44 (2006.01) A61K 31/50 (2006.01) A61K 31/519 (2006.01) C07D 213/56 (2006.01) C07D 213/70 (2006.01) C07D 213/75 (2006.01) C07D 237/18 (2006.01) C07D 241/20 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2274825

The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

Inhibiteurs de p38, une protéine kinase de mammifère qui intervient dans la prolifération cellulaire, la mort cellulaire et la réponse aux stimuli extracellulaires. L'invention porte également sur des procédés pour produire ces inhibiteurs ainsi que sur des compositions pharmaceutiques contenant ces derniers, et sur des méthodes d'utilisation de ces compositions dans le traitement et la prévention de divers troubles.

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