Substituted nitrogen-containing heterocycles as vanilloid...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/04 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2584167

Substituted nitrogen-containing heterocycles and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritus, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.

L'invention concerne des hétérocycles contenant de l'azote substitués ainsi que des compositions les comprenant, pour le traitement de douleurs aiguës, inflammatoires et neuropathiques, douleurs dentaires, maux de tête, migraine, algie vasculaire de la face, syndromes mixtes vasculaires et non vasculaires, maux de têtes dus à la tension, inflammations générales, arthrite, maladies rhumatismales, ostéoarthrite, troubles intestinaux inflammatoires, troubles oculaires inflammatoires, troubles de la vessie inflammatoires ou instables, psoriasis, douleurs de la peau avec composantes inflammatoires, conditions inflammatoires chroniques, douleurs inflammatoires et hyperalgésie et allodynie associées, douleurs neuropathiques et hyperalgésie et allodynie associées, douleurs liées à la neuropathie diabétique, causalgie, douleur maintenue de façon sympathique, syndromes de désafférentation, asthme, dégâts ou dysfonctionnement du tissu épithélial, herpès simplex, troubles de la mobilité viscérale au niveau de régions respiratoires, génito-urinaires, gastro-intestinales ou vasculaires, blessures, brûlures, réactions allergiques de la peau, prurit, vitiligo, troubles gastro-intestinaux généraux, ulcération gastrique, ulcères duodénaux, diarrhée, lésions gastriques dues à des agents nécrosants, croissance des cheveux, rhinite vasomotrice ou allergique, troubles des bronches ou troubles de la vessies.

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