Substituted nitrogen containing spiro compounds for use in...

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C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) C07D 209/96 (2006.01) C07D 241/38 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2118212

2118212 9321185 PCTABS00027 There are provided novel spirocyclic compounds of formula (I), or physiologically suitable salts thereof, wherein: X and Y are taken together to form a saturated or unsaturated carbocylic or heterocyclic first ring and the shown carbon in said ring is .alpha. to at least one additional aromatic ring or heteroaromatic ring fused to the first ring; Z is O, S, N-NH2, 2 hydrogen atoms, or H and OH; one of Het1 or Het2 is 2-, 3-, or 4-pyridyl, or 2-, 4-, or 5-pyrimidinyl and the other is selected from the group including: 2-, 3-, or 4-pyridyl, 2-, 4-, or 5-pyrimidinyl, 2-pyrazinyl, 3- or 4-pyridazinyl, 3- or 4-pyrazolyl, 2- or 3-tetrahydrofuranyl, and 3-thienyl; pharmaceutical compositions containing them and method of using them in mammals to treat cognitive deficiencies and/or neurological dysfunction and/or mood disturbances as found, for example, in degenerative nervous system diseases.

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