C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61K 31/53 (2006.01) A61P 35/00 (2006.01) C07D 239/08 (2006.01)
Patent
CA 2632452
The present invention provides 8-substituted O6-benzylguanine, 4(6)-substituted 2-amino-5-nitro-6(4)-benzyloxypyrimidine, and 4(6)-substituted 2-amino-5-nitroso-6(4)-benzyloxypyrimidine derivatives which have been found to be effective AGT inactivators, as well as pharmaceutical compositions comprising such derivatives along with a pharmaceutically acceptable carrier. The present invention further provides a method of enhancing the chemotherapeutic treatment of tumor cells in a mammal with an antineoplastic alkylating agent which causes cytotoxic lesions at the O6-position of guanine, by administering to a mammal an effective amount of one of the aforesaid derivatives, 2,4-diamino-6-benzyloxy-s-triazine, 5-substituted 2,4-diamino-6-benzyloxypyrimidines, or 8-aza-O6-benzylguanine, and administering to the mammal an effective amount of an antineoplastic alkylating agent which causes cytotoxic lesions at the O6-position of guanine.
Chae Mi-Young
Dolan M. Eileen
Moschel Robert C.
Pegg Anthony E.
Arch Development Corporation
Department O. F. Health And Human Services The United States Of America Represented By The Secretary
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
The Penn State Research Foundation
The United States Of America Represented By The Secretary Department Of Health And Human Services
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