C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/421 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 263/58 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2603826
The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl and Fit- 3 inhibitors.
Composés appartenant au groupe des dérivés d'oxazole substitués qui agissent sélectivement pour moduler, réguler et/ou inhiber la transduction de signal dont la médiation est assurée par certaines types natifs et/ou mutants de tyrosine kinase intervenant dans une série de maladies animales et humaines du type troubles de prolifération cellulaire, métaboliques, allergiques et dégénératifs, et plus précisément ces composés sont des inhibiteurs puissants et sélectifs de c-kit, bcr-abl et Flt-3.
Benjahad Abdellah
Croisy Martine
Grierson David
Moussy Alain
Ab Science
Centre National de La Recherche Scientifique (cnrs)
Institut Curie
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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