C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/56 (2006.01) A61K 31/426 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2393190
A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein; X1 represents O or S; R1 and R2 independently represent H, halogen, -CH3 and -OCH3; n represents 1 or 2; X2 represents NH, NCH3 or O; One of Y and Z is N, and the other is O or S; R3 represents phenyl or pyridyl (wherein the N is in position 2 or 3) and is optionally substituted by one or more halogen, NO2, NH2, CF3, OCF3, OC1-6 straight or branched alkyl, C1-6 straight or branched alkyl, alkenyl or alkynyl with the provision that when R3 is pyridyl, the N is unsubstituted; R4 represents CF3 or CH3.
La présente invention concerne un composé de formule (I) et des sels, solvates et esters hydrolysables, pharmaceutiquement acceptables dudit composé. Dans la formule (I): X?1¿ représente O ou S; R?1¿ et R?2¿ représentent indépendamment H, halogène, -CH¿3? et -OCH¿3?; n vaut 1 ou 2; X¿2? représente NH, NCH¿3? ou O; l'un des deux éléments Y et Z est N, et l'autre est O ou S; R?3¿ représente phényle ou pyridyle (où N se trouve en position 2 ou 3) et est éventuellement substitué par un ou plusieurs halogène, NO¿2?, NH¿2?, CF¿3?, OCF¿3?, OC¿1-6? alkyle ramifié ou non, C¿1-6? alkyle, alcényle ou alcynyle ramifié ou non, à la condition que, lorsque R?3¿ est pyridyle, N est non substitué; R?4¿ représente CF¿3? ou CH¿3?.
Glaxo Group Limited
Gowling Lafleur Henderson Llp
LandOfFree
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