C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/04 (2006.01) A61K 31/42 (2006.01) A61K 31/535 (2006.01) A61K 38/05 (2006.01) C07D 413/12 (2006.01) C07K 5/062 (2006.01)
Patent
CA 2210258
This invention relates to oxazolidine inhibitors of calpain and/or cathepsin B and to compositions containing them, having the general formula: (See formula I) As inhibitors of calpain and/or cathepsin B, the compounds are useful in the treatment of patients afflicted with acute or chronic neurodegenerative disorders.
La présente invention concerne des inhibiteurs de la calpaïne et/ou de la cathepsine B dérivés d'oxazolidine et des compositions les renfermant. En tant qu'inhibiteurs de la calpaïne et/ou de la cathepsine B, ces composés sont utiles dans le traitement de patients souffrant de troubles neurodégénératifs aigus ou chroniques.
Angelastro Michael R.
Kim Hwa-Ok
Linnik Matthew D.
Mehdi Shujaath
Peet Norton P.
Aventisub II Inc.
Hoechst Marion Roussel Inc.
Osler Hoskin & Harcourt Llp
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