Substituted oximes as neurokinin antagonists

Details Substituted oximes as neurokinin antagonists Substituted oximes as neurokinin antagonists

C - Chemistry, Metallurgy

07

D

C07D 211/76 (2006.01) A61K 31/445 (2006.01) C07D 211/24 (2006.01) C07D 211/34 (2006.01) C07D 211/52 (2006.01) C07D 211/58 (2006.01) C07D 211/64 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2309558

Compounds within the genus represented by structural formula (I) or a pharmaceutically acceptable salt thereof, wherein: T is substituted phenyl or substituted pyridyl; R1 is H, methyl, ethyl, -CH2CN, - CH2C(O)NH2, -(CH2)3SO3H, -CH2C(O)NHCH3, -CH2C(O)NHOH, -CH2C(O)NHOCH3, -CH2C(O)NHCH2CN, -CH2F, -CH2C(O)NHCH2SO3H, (a), (b), (c), (d) or (e); R4 is methyl or ethyl; and Z is substituted piperidinyl.

Composés représentés par la formule suivante (I) ou un de leurs sels acceptables sur le plan pharmaceutique, dans laquelle T représente phényle substitué ou pyridyle substitué; R<1> représente H, méthyle, éthyle, -CH2CN, -CH2C(O)NH2, -(CH2)3SO3H, -CH2C(O)NHCH3, -CH2C(O)NHOH, -CH2C(O)NHOCH3, -CH2C(O)NHCH2CN, -CH2F, -CH2C(O)NHCH2SO3H, (a), (b), (c), (d) ou (e); R<4> représente méthyle ou éthyle; Z représente pipéridinyle substitué.

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