Substituted phenol ester containing compounds

C - Chemistry – Metallurgy – 07 – C

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260/293.1, 260/2

C07C 69/712 (2006.01) C07D 213/80 (2006.01)

Patent

CA 1135689

ABSTRACT A process for producing pharmaceutically active compounds of the general formula Image Wherein R1 = a) Image where n = 3 - 12 m = O - 1 z = O - 1 b) Image where m = O - 1 and z = O - l c) Cumyl d) p-Chlorobenzoyl e) 1-Piperidinyl f) 2-Pyrimidinyl or, g) Hydrogen, when R2 equals cycloalkyl or cycloalkylene (-CH2-)n, and R2 = a) (-CH2-)n, where n = O or 4 b) Halogen c) C1-C6-Alkyl or cycloalkyl d) Methoxy e) Ethoxy f) trifluoromethyl g) Nitro or, h) Hydrogen and R3 = a) Image or, b) 2-Methyl-2-(p-chlorophenoxy)-propionyl in which a butyric or nicotinic acid halide is esterified with a phenol in the presence of an acid binding substance such as pyridine; and the pharmaceutically acceptable salts of such process which are useful in the treatment of arterosclerosis

345303

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