C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 491/048 (2006.01) A61K 31/40 (2006.01) A61K 31/407 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2119783
The present invention relates to substituted phenylcarbamate or naphthylcarbamate tricyclic compounds of formula (I), wherein R is -O- or NRi, which provide highly potent and selective cholinergic agonist and blocking activity and their use as pharmaceutical agents. The invention further relates to improvements in therapy relative to cholinergic diseases such as glaucoma, Myasthenia Gravis, Alzheimer's disease and to improvements in therapy and organophosphate poisoning. The invention further provides for a selective acetylcholinesterase and butyrylcholinesterase agents and a method for inhibiting these esterases.
Brossi Arnold
Brzostowska Malgorzata
Greig Nigel H.
He Xiao-Shu
Rapoport Stanley I.
Shapiro Cohen
The Government Of The United States Of America Represented By Th
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