(substituted-phenyl)-5-oxo-pyrrolidine-2-propanoic acids and...

Details (substituted-phenyl)-5-oxo-pyrrolidine-2-propanoic acids and... (substituted-phenyl)-5-oxo-pyrrolidine-2-propanoic acids and...

C - Chemistry, Metallurgy

07

D

167/233, 260/324

C07D 207/267 (2006.01) A61K 31/40 (2006.01) C07D 207/26 (2006.01)

Patent

CA 1235706

ABSTRACT Certain 5-oxo-3-(unsubstituted-phenyl)- or 5-oxo-3- (substituted-phenyl)-2-pyrrolidinepropanoic acids and 5-oxo-.beta.- (unsubstituted-phenyl)- or 5-oxo-.beta.-(substituted-phenyl)-2- pyrrolidinepropanoic acids, their pharmaceutically acceptable esters and metal and amine cation salts, pharmaceutical compositions employing these compounds, and a method of treating senility or of reversing amnesia are disclosed. The compounds have the general formula: Image (I) or Image (II) wherein * represents an asymmetrical carbon center, R represents H, phenyl, phenylmethyl or C1-6alkyl, and X and Y, independently, represent H, Cl, -CF3, C1-6alkyl or C1-6alkoxy.

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