Substituted phenylacetamides and their use as glucokinase...

Details Substituted phenylacetamides and their use as glucokinase... Substituted phenylacetamides and their use as glucokinase...

C - Chemistry, Metallurgy

07

D

C07D 277/46 (2006.01) A61K 31/17 (2006.01) A61K 31/404 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61P 3/10 (2006.01) C07C 317/44 (2006.01) C07D 209/18 (2006.01) C07D 213/56 (2006.01) C07D 213/75 (2006.01) C07D 213/80 (2006.01) C07D 277/56 (2006.01) C07D 295/155 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2407759

Compounds of formula (I) wherein X is oxygen or sulfonyl, R is a ring, R1 is cycloalkyl, y and z are 0 or 1, and R2 is -CO-NHR3 or a heteroaromatic ring having a ring nitrogen atom adjacent to the connecting ring carbon atom, are active as glucokinase activators to increase insulin secretion, which makes them useful for treating type II diabetes.

L'invention concerne des composés de formule (I) dans laquelle X désigne un oxygène ou un soufre, R représente un cycle, R<1> représente un cycloalkyle, y et z sont égaux à 0 ou 1, et R<2> désigne -CO-NHR<3> ou un cycle hétéroaromatique présentant un atome d'azote qui est adjacent à l'atome de carbone de liaison. Ces composés peuvent être utilisés comme activateurs de la glucokinase aux fins d'augmenter la sécrétion d'insuline, ces composés étant, par conséquent, utiles pour traiter les diabètes du type II.

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