Substituted phenylpiperazine compounds as antihypertensive...

C - Chemistry – Metallurgy – 07 – D

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C07D 295/12 (2006.01) C07D 233/72 (2006.01) C07D 295/13 (2006.01) C07D 403/06 (2006.01)

Patent

CA 1204754

ABSTRACT Compounds of general formula Image (I) wherein: n is 2, 3 or 4; A is Image (A1) Image (A2); and R1 is H, C1-6 alkyl or C1-6 alkoxy; with the provisos: (i) when n is 3 and A is (A1), R1 is not 3-OCH3, (ii) when n is 3 and A is (A2), R1 is not 2-OCH3 or 4-OCH3, and (iii) when n is 4 and A is (A2), R1 is not 4-CH3 or 4-OCH3 are disclosed. Processes for preparing these compounds and their use as antihypertensive agents are also disclosed.

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