C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 235/20 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 45/06 (2006.01) A61P 3/00 (2006.01)
Patent
CA 2469302
The present invention provides the S enantiomer of a compound of formula (I); wherein R1 represents 2,4-difluorophenyl or cyclohexyl as well as pharmaceutically acceptable salts, solvates, crystalline forms and prodrugs thereof, to processes for preparing such compounds, to their the utility in treating clinical conditions including lipid disorders (dyslipidemias) whether or not associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.
L'invention concerne un énantiomère S d'un composé de formule (I), dans laquelle R?1¿ représente 2, 4-difluorophényle ou cyclohéxyle ainsi que ses sels pharmaceutiquement acceptables, ses formes cristallines et ses promédicaments. L'invention concerne également des procédés de préparation desdits composés, leur utilité dans le traitement clinique d'états cliniques notamment des troubles lipidiques (dyslipidémie) associés ou non à une résistance à l'insuline, des procédés d'utilisation thérapeutique, ainsi que des compositions pharmaceutiques les contenant.
Alstermark Lindstedt Eva-Lotte
Li Lanna
Olsson Anna Christina
Astrazeneca Ab
Fetherstonhaugh & Co.
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