Substituted phenylsulfonamide inhibitors of beta amyloid...

Details Substituted phenylsulfonamide inhibitors of beta amyloid... Substituted phenylsulfonamide inhibitors of beta amyloid...

C - Chemistry, Metallurgy

07

C

C07C 311/17 (2006.01) A61K 31/18 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2486581

Compounds of Formula I, wherein R1-R8 are defined herein are provided, together with pharmaceutically acceptable salts, hydrates, metabolites, and/or prodrugs thereof. Uses of these compounds for inhibiting beta amyloid production and for the prevention and treatment of Alzheimer~s Disease and Down~s syndrome are described.

L'invention concerne des composés représentés par la formule I dans laquelle R¿1?-R¿8? sont tels que définis dans la description; et des sels pharmaceutiquement acceptables, des hydrates, des métabolites et/ou des promédicaments de ceux-ci. La présente invention concerne les utilisations de ces composés pour inhiber la production de bêta-amyloïdes et pour traiter et prévenir la maladie d'Alzheimer et le syndrome de Down.

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