Substituted piperazine as melanocortin receptors ligands

Details Substituted piperazine as melanocortin receptors ligands Substituted piperazine as melanocortin receptors ligands

C - Chemistry, Metallurgy

07

D

C07D 413/14 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61K 31/506 (2006.01) A61K 31/5377 (2006.01) A61K 31/5513 (2006.01) A61P 3/04 (2006.01) C07D 207/14 (2006.01) C07D 207/16 (2006.01) C07D 207/27 (2006.01) C07D 207/273 (2006.01) C07D 207/335 (2006.01) C07D 211/14 (2006.01) C07D 211/26 (2006.01) C07D 211/28 (2006.01) C07D 211/58 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01) C07D 213/38 (2006.01) C07D 213/74 (2006.01) C07D 217/26 (2006.01) C07D 223/04 (2006.01) C07D 233/36 (2006.01) C07D

Patent

CA 2484968

Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein Ar, R1, R2, R3a, R3b, R4a, R4b, R5, R7a, R7b, q, r, X, Y1, Y2, Y3 and Y4 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

L'invention concerne des composés qui jouent le rôle de ligands du récepteur de la mélanocortine, et sont utiles pour le traitement de troubles liés au récepteur de la mélanocortine. Lesdits composés sont représentés par la formule (I), où Ar, R¿1?, R¿2?, R¿3a?, R¿3b?, R¿4a?, R¿4b?, R¿5?, R¿7a?, R¿7b?, q, r, X, Y¿1?, Y¿2?, Y¿3? et Y¿4?, sont tels que définis dans le descriptif de l'invention. L'invention a également trait à des stéréo-isomères, des promédicaments et des sels pharmaceutiquement acceptables desdits composés. Elle se rapporte aussi à des compositions pharmaceutiques contenant un composé représenté par la formule (I), ainsi qu'à des procédés d'utilisation de celles-ci.

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