Substituted piperazine compounds

Details Substituted piperazine compounds Substituted piperazine compounds

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61K 31/498 (2006.01) A61P 9/00 (2006.01) C07D 241/08 (2006.01) C07D 241/42 (2006.01) C07D 295/108 (2006.01) C07D 295/15 (2006.01)

Patent

CA 2400176

Novel compounds of the general formula: Image and pharmaceutically acceptable acid addition salts thereof, wherein the compounds are useful in therapy to protect skeletal muscles against damage resulting from trauma or to protect skeletal muscles subsequent to muscle or systemic diseases such as intermittent claudication, to treat shock conditions, to preserve donor tissue and organs used in transplants, in the treatment of cardiovascular diseases including atrial and ventricular arrhythmias, Prinzmetal's (variant) angina, stable angina, and exercise induced angina, congestive heart disease, and myocardial infarction.

L'invention concerne de nouveaux composés selon la formule générale (I). L'invention traite également de sels d'addition acides pharmaceutiquement acceptables de ces derniers. Ces composés présentent une grande utilité en thérapie pour protéger les musques squelettiques contre les traumatismes ou contre des maladies systémiques ou musculaires comme la claudication intermittente. Ils permettent également de traiter des états de choc, de préserver les organes et les tissus des donneurs au cours des transplantations, de traiter les maladies cardiovasculaires parmi lesquelles des arythmies atriales et ventriculaires, l'angine de poitrine inversée, l'angine de poitrine stable, et l'angine de poitrine induite par les exercices, les maladies cardiaques congestives et l'infarctus du myocarde.

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