Substituted piperazine derivatives,the preparation thereof...

Details Substituted piperazine derivatives,the preparation thereof... Substituted piperazine derivatives,the preparation thereof...

C - Chemistry, Metallurgy

07

D

C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61P 7/00 (2006.01) C07D 209/18 (2006.01) C07D 213/56 (2006.01) C07D 219/02 (2006.01) C07D 233/54 (2006.01) C07D 241/08 (2006.01) C07D 243/08 (2006.01) C07D 295/185 (2006.01) C07D 295/192 (2006.01) C07D 295/205 (2006.01) C07D 295/215 (2006.01) C07D 295/26 (2006.01) C07D 311/84 (2006.01) C07D 317/60 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 2394644

The invention relates to substituted piperazine derivatives of general formula (I), wherein Ra to Rc, Ya, Yb, X and n have the meanings given in claim no.1, and isomers and salts thereof, especially physiologically suitable salts thereof, which are valuable inhibitors of microsomal triglyceride transfer protein (MTP). The invention also relates to medicaments containing these compounds, and to the use and production of said compounds.

La présente invention concerne des dérivés de pipérazine substitués de la formule générale (I) où R¿a? à R¿c?, Y¿a?, Y¿b?, X et n ont la signification donnée dans la revendication (1), leurs isomères et leurs sels, notamment leurs sels physiologiquement tolérables, qui sont de précieux inhibiteurs de la protéine de transfert triglycéride microsomale (MTP). L'invention concerne également des médicaments contenant des composés, leur utilisation et leur production.

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