Substituted piperazines as cb1 antagonists

C - Chemistry – Metallurgy – 07 – D

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C07D 241/04 (2006.01) A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2589483

Compounds of Formula (I): Chemical formula should be inserted here as it appears on the abstract in paper form. or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

La présente invention a trait à des composés de formule (I), ou leurs sels, solvates ou esters pharmaceutiquement acceptables, utiles dans le traitement de maladies ou conditions où sont impliqués les récepteurs CB1, tels que le syndrome métabolique et l'obésité, les troubles neuroinflammatoires, les troubles cognitifs et la psychose, l'accoutumance (par exemple, le sevrage du tabac), les troubles gastro-intestinaux, et les conditions cardio-vasculaires.

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