C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/496 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2454903
Selected substituted piperazine compounds are effective for prophylaxis and treatment of diseases, such as obesity and the like. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving activation of the melanocortin receptor. The subject invention also relates to processes For making such compounds as well as to intermediates useful in such processes.
L'invention concerne des composés de pipérazines substituées choisis, efficaces au niveau de la prophylaxie et du traitement de maladies telles que l'obésité et analogues. Elle concerne également de nouveaux composés, analogues, promédicaments et des sels de ceux-ci pharmaceutiquement acceptables, des compositions pharmaceutiques et des procédés de prophylaxie et de traitement de maladies et autres états impliquant l'activation du récepteur de mélanocortine. L'invention concerne enfin des processus de fabrication de tels composés ainsi que des intermédiaires utilisés dans de tels processus.
Arasasingham Premilla
Bo Yunxin
Chen Ning
Fotsch Christopher H.
Goldberg Martin H.
Amgen Inc.
Gowling Lafleur Henderson Llp
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