C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/451 (2006.01) A61K 31/4725 (2006.01) A61P 3/04 (2006.01) A61P 15/00 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 211/62 (2006.01) C07D 295/12 (2006.01) C07D 401/12 (2006.01) C07D 521/00 (2006.01)
Patent
CA 2519440
The present invention relates to novel substituted piperidine and piperazine derivatives as melanocortin-4 receptor (MC-4R) modulators. MC-4R agonists of the invention can be used for the treatment of disorders and diseases such as obesity, diabetes and sexual dysfunction, whereas the MC-4R antagonists are useful for the treatment of disorders and diseases such as cancer cachexia, muscle wasting, anorexia, anxiety and depression. All diseases and disorders, where the regulation of the MC-4R is involved, can be treated with the compounds of the invention.
L'invention concerne de nouveaux dérivés de pipéridine et de pipérazine substitués, utilisés en tant que modulateurs du récepteur de la mélanocortine-4 (MC-4R). Les agonistes du MC-4R selon l'invention peuvent être utilisés dans le traitement des troubles et maladies, tels que l'obésité, le diabète et les dysfonctionnements sexuels, alors que les antagonistes du MC-4R sont utilisés dans le traitement des troubles et maladies, tels que la cachexie cancéreuse, l'atrophie musculaire, l'anorexie, l'angoisse et la dépression. Tous les troubles et maladies impliquant la régulation du MC-4R peuvent être traités au moyen des composés selon l'invention.
Henneboehle Marco
Soeberdt Michael
von Sprecher Andreas
Weyermann Philipp
Robic
Santhera Pharmaceuticals (schweiz) Gmbh
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