C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/10 (2006.01) A61K 31/435 (2006.01) A61P 3/04 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) A61P 25/18 (2006.01) A61P 25/20 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2745721
The present invention discloses and claims a series of substituted N-phenyl- bipyrrolidine carboxamides of formula (I), wherein R1, R2, R3, m, n and p are as described herein. More specifically, the compounds of this invention are modulators of H3 receptors and are, therefore, useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases modulated by H3 receptors including diseases associated with the central nervous system. Additionally, this invention also discloses methods of preparation of substituted N-phenyl-bipyrrolidine carboxamides and intermediates therefor.
La présente invention concerne une série de carboxamides de N-phényl-bipyrrolidine substitués de formule (I) dans laquelle: R1, R2, m, n et p sont tels que définis dans la description. Dune manière plus spécifique, les composés selon linvention sont des modulateurs des récepteurs de H3 et sont donc utiles en tant quagent pharmaceutiques, notamment dans le traitement et/ou la prévention de diverses maladies modulées par les récepteurs de H3 comprenant les maladies associées au système central nerveux. En outre, la présente invention concerne également des procédés de préparation de carboxamides de N-phényl-bipyrrolidine substitués et des intermédiaires utilisés à cet effet.
Gao Zhongli
Hall Daniel
Hartung Ryan
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi
LandOfFree
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