Substituted piperidines as melanocortin receptor agonists

Details Substituted piperidines as melanocortin receptor agonists Substituted piperidines as melanocortin receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/496 (2006.01) A61P 15/10 (2006.01) C07D 401/14 (2006.01) C07D 413/14 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2403686

Certain novel substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in partic-ular, are selective agonists of the human melanocortin-4 receptor (MC- 4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

L'invention concerne des composés de pipéridine substituée qui sont des agonistes du récepteur(s) de la mélanocortine humaine et qui sont, en particulier, des agonistes sélectifs du récepteur de la mélanocortine-4 humaine (MC-4R). Il sont donc utiles pour le traitement, la lutte contre ou la prévention de maladies et de troubles sensibles à l'activation du récepteur MC-4R, tels que l'obésité, les diabètes, le dysfonctionnement sexuel, y compris les dysfonctionnements érectile et sexuel féminin.

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