Substituted piperidines as melanocortin receptor agonists

Details Substituted piperidines as melanocortin receptor agonists Substituted piperidines as melanocortin receptor agonists

C - Chemistry, Metallurgy

07

D

C07D 417/02 (2006.01) A61K 31/445 (2006.01) A61K 31/451 (2006.01) A61K 31/4523 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) C07D 211/06 (2006.01) C07D 211/20 (2006.01) C07D 211/24 (2006.01) C07D 211/26 (2006.01) C07D 211/62 (2006.01) C07D 401/02 (2006.01) C07D 401/06 (2006.01) C07D 409/12 (2006.01) C07D 413/02 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 487/08 (2006.01) C07D 491/08 (2006.01)

Patent

CA 2419310

Certain novel 4-substituted piperidine compounds are agonists of the human melanocortin receptor(s) and, in particular, are selective agonists of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

Certains composés de pipéridine 4-substitués sont des agonistes du ou de récepteur(s) de la mélanocortine humaine et, en particulier, des agonistes sélectifs du récepteur de la mélanocortine-4 humaine (MC-4R). Par voie de conséquence, ils sont utiles pour le traitement, l'atténuation ou la prévention de maladies et de troubles dus à l'activation de MC-4R, tels que l'obésité, le diabète, les dysfonctionnements sexuels chez l'homme, dont les troubles de l'érection, et chez la femme.

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