C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01) C07D 473/34 (2006.01)
Patent
CA 2672841
The invention provides compounds of the formula (I) having PKA and PKB kinase inhibiting compounds of the formula (I): GP 1 J T 2 J N 4 R N H (I) or salts, solvates, tautomers or N-oxides thereof, wherein (1) GP is a group GP1: HET 2a a Q G (HNCO)f 7 (R )x N * (GP1) (2) GP is a group GP2: 10 (R )r O 2a a QG (CH2)w N V H N * (GP2) wherein HET is a monocyclic or bicyclic heterocyclic group containing up to 4 heteroatom ring members; the ring V is a monocyclic or bicyclic heteroaryl group of 5 to 10 ring members; and J1, J2, R4, R7, R10, Q2a, Ga, x, w and f are as defined in the claims
L'invention concerne des composés de formule (I) ayant des composés inhibant PKA et PKB kinase de formule (I): GP 1 J T 2 J N 4 R N H (I) ou des sels, des solvates, des tautomères ou des N-oxydes de ceux-ci, formule (1) dans laquelle GP représente un groupe GP1: HET 2a a Q G (HNCO)f 7 (R )x N * (GP1) (2) GP représente un groupe GP2: 10 (R )r O 2a a QG (CH2)w N V H N * (GP2) où HET représente un groupe hétérocyclique monocyclique ou bicyclique contenant jusqu'à 4 éléments du noyau d'hétéroatome; le noyau V est un groupe hétéroaryle monocyclique ou bicyclique de 5 à 10 éléments; et J1, J2, R4, R7, R10, Q2a, Ga, x, w et f sont tels que définis dans les revendications.
Caldwell John
Carr Gregory Richard
Cheung Kwai Ming
Collins Ian
Da Fonseca Mchardy Tatiana Faria
Astex Therapeutics Limited
Astrazeneca Ab
Cancer Research Technology Limited
Fetherstonhaugh & Co.
The Institute Of Cancer Research: Royal Cancer Hospital
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