Substituted polycyclic aryl and heteroaryl...

Details Substituted polycyclic aryl and heteroaryl... Substituted polycyclic aryl and heteroaryl...

C - Chemistry, Metallurgy

07

C

C07C 215/16 (2006.01) A61K 31/135 (2006.01) A61K 31/33 (2006.01) C07C 215/50 (2006.01) C07C 215/76 (2006.01) C07C 217/58 (2006.01) C07C 217/84 (2006.01) C07C 217/86 (2006.01) C07C 217/88 (2006.01) C07C 217/90 (2006.01) C07C 225/22 (2006.01) C07C 229/60 (2006.01) C07C 233/69 (2006.01) C07C 235/38 (2006.01) C07C 237/30 (2006.01) C07C 237/38 (2006.01) C07C 255/55 (2006.01) C07C 255/58 (2006.01) C07C 275/34 (2006.01) C07C 311/04 (2006.01) C07C 311/21 (2006.01) C07C 311/24 (2006.01) C07C 311/60 (2006.01) C07C 31

Patent

CA 2345118

The invention relates to substituted polycyclic aryl and heteroaryl tertiary- heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.

L'invention concerne des composés à base d'aryl- et d'hétéroaryl-hétéroalkylamines tertiaires polycycliques substituées, utiles comme inhibiteurs de l'activité de la protéine de transfert de l'ester de cholestéryle (CETP, protéine de transfert des lipides plasmatiques 1), ainsi que des composés, des compositions et des méthodes permettant de traiter l'athérosclérose et d'autres maladies des artères coronaires.

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