Substituted polycyclic aryl and heteroaryl pyridones useful...

Details Substituted polycyclic aryl and heteroaryl pyridones useful... Substituted polycyclic aryl and heteroaryl pyridones useful...

C - Chemistry, Metallurgy

07

D

C07D 213/77 (2006.01) A61K 31/44 (2006.01) A61K 31/4427 (2006.01) A61K 31/47 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) C07D 213/74 (2006.01) C07D 213/75 (2006.01) C07D 215/38 (2006.01) C07D 401/12 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2373509

The invention relates to substituted polycyclic aryl and heteroaryl pyridone compounds having Formula (I) or a pharmaceutically acceptable salt thereof, wherein: a.o., ~ is selected from the group consisting of NH and NOH; useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment and prevention of a variety of thrombotic conditions including coronary artery and cerebrovascular diseases.

L'invention concerne des composés de pyridone aryle et hétéroaryle polycycliques substitués de formule (I) ou un sel pharmaceutiquement acceptable desdits composés, a, o et ~ étant choisis dans le groupe constitué par NH et NOH, utilisés comme inhibiteurs de sérine protéases de la cascade de coagulation. L'invention concerne également des composés, des compositions et des méthodes utilisés dans la thérapie anticoagulante pour le traitement et la prévention de nombreux états thrombotiques, tels que les coronaropathies et les affections cérébrovasculaires.

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