Substituted propanamide derivative and pharmaceutical...

A - Human Necessities – 61 – K

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Details

A61K 31/167 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 35/04 (2006.01) C07C 237/22 (2006.01)

Patent

CA 2615991

An object of the invention is to provide a substituted propanamide derivative or a pharmacologically acceptable salt thereof which is useful as a preventive agent or a therapeutic agent for a disease related to bone metabolism. The invention is directed to a pharmaceutical composition containing, as a active ingredient, a compound having the general formula (I): (wherein R1 represents a C6-C10 aryl group which may be substituted with a group selected from the substituent group .alpha. or the like, R2 represents a C6-C10 aryl group which may be substituted with a group selected from the substituent group .alpha. or the like and X represents a hydroxyl group, a C1-C6 alkoxy group or the like) or a pharmacologically acceptable salt thereof.

L'invention a pour objet un dérivé de propanamide substitué ou un sel acceptable du point de vue pharmacologique de celui-ci lequel est utile comme agent préventif ou agent thérapeutique pour une maladie liée au métabolisme osseux. L'invention concerne une composition pharmaceutique contenant, comme ingrédient actif, un composé ayant la formule générale (I) : (où R1 représente un groupe aryle en C6-C10 qui peut être substitué par un groupe sélectionné dans le groupe .alpha. des substituants ou similaires, R2 représente un groupe aryle en C6-C10 qui peut être substitué par un groupe sélectionné dans le groupe .alpha. des substituants ou similaires et X représente un groupe hydroxyle, un groupe alcoxy en C1-C6 ou similaires) ou un sel acceptable du point de vue pharmacologique de celui-ci.

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