Substituted purine derivatives as inhibitors of cell adhesion

Details Substituted purine derivatives as inhibitors of cell adhesion Substituted purine derivatives as inhibitors of cell adhesion

C - Chemistry, Metallurgy

07

D

C07D 473/34 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2376673

The present invention relates to compounds of formula (I), in which B, D, E, G, X, Y, Z, R1, R2 and s have the meanings indicated in the claims, their physiologically tolerable salts and their prodrugs. The compounds of formula (I) are valuable pharmacologically active compounds. They are vitronectin receptor antagonists and inhibitors of cell adhesion and are suitable for the therapy and prophylaxis of illnesses which are based on the interaction between vitronectin receptors and their ligands in cell-cell or cell-matrix interaction processes or which can be prevented, alleviated or cured by influencing such interactions. For example, they can be applied for inhibiting bone resorption by osteoclasts and thus for treating and preventing osteoporosis, or for inhibiting undesired angiogenesis or proliferation of cells of the vascular smooth musculature. The invention furthermore relates to processes for the preparation of compounds of formula (I), their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.

Cette invention a trait à des composés correspondant à la formule (I), dans laquelle B, D, E, G, X, Y, Z, R?1¿, R?2¿ et s ont les significations indiquées dans les revendications, à leurs sels admissibles du point de vue physiologique et à leurs promédicaments. Les composés correspondant à la formule (I) constituent de précieux composés pharmaceutiquement actifs. Ils sont des antagonistes du récepteur de la vitronectine et des inhibiteurs de l'adhésion cellulaire et se prêtent à la thérapie et à la prophylaxie de maladies, liées à l'interaction entre les récepteurs de la vitronectine et leurs ligands dans des processus d'interaction cellule-cellule ou cellule-matrice, ou de maladies pouvant être évitées, soulagées ou soignées par l'exercice d'une influence sur ces interactions. On peut les utiliser, notamment pour inhiber la résorption osseuse par des ostéoclastes et, partant, pour prévenir et traiter l'ostéoporose, ou pour inhiber une angiogenèse indésirable ou une prolifération des cellules des muscles lisses vasculaires. Cette invention concerne, de surcroît, des procédés de préparation de composés correspondant à la formule (I), leur utilisation, notamment comme ingrédients actifs dans des produits pharmaceutiques et des compositions pharmaceutiques les renfermant.

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