A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/52 (2006.01) A61K 31/20 (2006.01) A61K 31/23 (2006.01) A61K 31/417 (2006.01) A61P 35/00 (2006.01) A61P 39/00 (2006.01)
Patent
CA 2578993
The present invention describes new biological activities of immunomodulating 6-substituted purinyl compounds which make them particularly useful during the treatment of cancer. Collectively, these new biological activities make these purinyl compounds useful chemoprotective agents for the treatment of myelosuppression which is associated with cancer chemotherapy and/or radiotherapy. This chemoprotective activity is in addition to the immunomodulating and subsequent anticancer activity displayed by these compounds, The chemoprotective usefulness of these compounds is further enhanced by the use of medium-chain fatty acids or salts or triglycerides or mono- or diglycerides in combination with the 6-substituted purinyl compounds of this invention.
La présente invention concerne de nouvelles activités biologiques de composés purinyle 6-substitués immunomodulateurs qui les rendent particulièrement utiles dans le traitement du cancer. Collectivement, ces nouvelles activités biologiques rendent les composés purinyle utiles comme agents chimioprotecteurs dans le traitement de la myélosuppression qui est associée à la chimiothérapie et/ou à la radiothérapie anticancéreuse. Les composés de l'invention déployent cette activité chimioprotectrice en plus de leur activité immunomodulatrice et de l'activité anticancéreuse qui en résulte. On peut en outre renforcer l'utilité chimioprotectrice desdits composés en utilisant des acides gras à chaîne moyenne ou des sels ou des triglycérides ou des mono ou diglycérides combinés aux composés purinyle 6-substitués de l'invention.
Barabe Jean
Gagnon Lyne
Laurin Pierre
Penney Christopher
Zacharie Boulos
Fasken Martineau Dumoulin Llp
Prometic Biosciences Inc.
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