Substituted pyranone inhibitors of cholesterol synthesis

Details Substituted pyranone inhibitors of cholesterol synthesis Substituted pyranone inhibitors of cholesterol synthesis

C - Chemistry, Metallurgy

07

D

260/359.4

C07D 309/28 (2006.01) C07D 309/30 (2006.01)

Patent

CA 1137989

16364IA TITLE OF THE INVENTION SUBSTITUTED PYRANONE INHIBITORS OF CHOLESTEROL SYNTHESIS ABSTRACT OF THE DISCLOSURE 6-Phenyl-, phenalkyl- and phenylethenyl- 4-hydroxytetrahydropyran-2-ones in the 4- R trans stereoisomeric forms are potent inhibitors of cholesterol synthesis by the enzyme hydroxymethyl- glutaryl coenzyme A reductase.

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