C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/495 (2006.01) A61P 25/00 (2006.01) C07D 241/00 (2006.01)
Patent
CA 2431970
The present invention is directed to novel compounds represented by structural Formulas (I) and (I-a), or a pharmaceutically acceptable salt thereof, wherein R1, R4a, R4b, R5, R6, R7, R8, R9, n, and X are described. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are serotonin agonists and antagonists and are useful in the control or prevention of central nervous system disorders including obesity, anxiety, depression, psychosis, schizophrenia, sleep and sexual disorders, migraine and other conditions associated with cephalic pain, social phobias, and gastrointestinal disorders such as dysfunction of the gastrointestinal tract motility.
L'invention concerne des nouveaux composés représentés par les formules développées (I) et (I-a), ou un sel de ces composés acceptable sur le plan pharmaceutique, R1, R4a, R4b, R5, R6, R7, R8, R9, n, et X étant décrits dans la demande. L'invention concerne également des préparations pharmaceutiques comprenant ces nouveaux composés en tant que principes actifs, l'utilisation de ces composés et de leurs préparations dans le traitement des certaines affections. Les composés de cette invention sont des agonistes et des antagonistes de sérotonine et servent à traiter ou à prévenir les troubles du système nerveux central tels que obésité, anxiété, dépression, psychose, schizophrénie, troubles du sommeil, troubles sexuels, migraines, états associés aux douleurs céphaliques, phobies sociales et troubles gastro-intestinaux, tels que les dysfonctionnements de la motilité du tube digestif.
Chen Wenting
Lee Taekyu
Mitchell Ian S.
Robichaud Albert
Bristol-Myers Squibb Pharma Company
Gowling Lafleur Henderson Llp
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