C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61K 31/55 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01)
Patent
CA 2743018
Provided are substituted pyrazole compounds which are useful as protein kinase inhihstors, compositions compnsmg the compounds, and methods of use thereof. The protein kinase inhibitors are particularly for inhibition of Aurora A i Aurora-2) protein kinase and are useful m Me treatment of diseases associated with protein kinases, especially diseases associated with Aurora-2, such as cancer.
La présente invention concerne des composés pyrazoliques substitués qui sont utiles en tant qu'inhibiteurs de protéine kinase, des compositions comprenant les composés, et des procédés d'utilisation de ceux-ci. Les inhibiteurs de protéine kinase sont particulièrement adaptés pour l'inhibition de la protéine kinase Aurora A (Aurora-2) et sont utiles dans le traitement de maladies associées à des protéine kinases, en particulier des maladies associées à Aurora-2, telle que le cancer.
Agoston Gregory E.
Ladouceur Gaetan
Ofoegbu Nnamdi
Shah Jamshed H.
Suwandi Lita
Finlayson & Singlehurst
Miikana Therapeutics Inc.
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