Substituted pyrazoles as modulators of chemokine receptors

Details Substituted pyrazoles as modulators of chemokine receptors Substituted pyrazoles as modulators of chemokine receptors

C - Chemistry, Metallurgy

07

D

C07D 231/22 (2006.01) A61K 31/415 (2006.01) A61K 31/4155 (2006.01) A61K 31/4178 (2006.01) A61K 31/4439 (2006.01) C07D 231/12 (2006.01) C07D 231/38 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)

Patent

CA 2595936

Substituted pyrazole compounds such compounds represented by formula I: which are used to modulate the CCR-2 chemokine receptor to prevent or treat inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis; and pharmaceutical compositions comprising these compounds and the use of these compounds and compositions.

L'invention concerne des composés de pyrazole substitués représentés par la formule I, qui sont utilisés pour moduler le récepteur des chimiokines CCR-2 afin de prévenir ou de traiter des troubles et des maladies inflammatoires et liées à l'immunomodulation, des maladies allergiques, des états atopiques comprenant la rhinite allergique, la dermatite, la conjonctivite et l'asthme, ainsi que des pathologies auto-immunes telles que la polyarthrite rhumatoïde et l'athérosclérose. L'invention concerne aussi des compositions pharmaceutiques comprenant ces composés ainsi que l'utilisation de ces composés et compositions.

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