Substituted pyrazoloquinolines and derivatives thereof

Details Substituted pyrazoloquinolines and derivatives thereof Substituted pyrazoloquinolines and derivatives thereof

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/4439 (2006.01) A61P 25/18 (2006.01) C07D 491/113 (2006.01)

Patent

CA 2741303

The present invention relates to substituted pyrazoloquinolines of formula I and derivatives thereof, the use of the compounds as phosphodiesterase 10 (PDE1O) inhibitors for the treatment of PDE1O -modulated disorders, to pharmaceutical compositions comprising the compounds, and to the use of additional substituted pyrazoloquinolines and derivatives thereof for the treatment of PDE1O -modulated disorders.

La présente invention porte sur des pyrazoloquinoléines substituées de formule I et sur des dérivés de celles-ci, sur l'utilisation des composés comme inhibiteurs de phosphodiestérase 10 (PDElO) pour le traitement de troubles modulés par PDElO, sur des compositions pharmaceutiques comprenant les composés et sur l'utilisation de pyrazoloquinoléines substituées supplémentaires et dérivés de celles-ci pour le traitement de troubles modulés par PDElO.

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