C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/415 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 231/10 (2006.01) C07D 231/54 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2276946
The present invention is related to substituted pyrazolyl benzenesulfonamides of the Formula I (see formula I) wherein R2 is selected from hydrido, C1-C10- alkyl, C1-C6-haloalkyl, C1-C6-alkoxycarbonyl, cyano, carboxyl, C1-C6- cyanoalkyl, aminocarbonyl, C1-C6-alkylaminocarbonyl, C3-C7- cycloalkylaminocarbonyl, arylaminocarbonyl, C1-C6-carboxyalkylaminocarbonyl, aryl-C1-C6- alkoxycarbonyl-C1-C10-alkylaminocarbonyl, C1-C6- aminocarbonylalkyl, C1-C6-carboxyalkyl, C1-C6-alkoxycarbonylcyano-C2-C6- alkenyl and C1-C6-hydroxyalkyl; wherein R3 is selected from hydrido, C1-C10- alkyl, cyano, C1-C6-hydroxyalkyl, C3-C7-cycloalkyl, C1-C6-alkylsulfonyl, and halo; and wherein R4 is selected from optionally substituted C3-C10- cycloalkyl, C3-C10-cycloalkenyl and heterocyclic; provided R2 and R3 are not both hydrido, further provided that R4 is not triazolyl when R2 is methyl; and further provided that R4 is not substituted thienyl when R2 is trifluoromethyl; or a pharmaceutically-acceptable salt thereof. The invention is also related to pharmaceutical compositions containing such compounds.
Bertenshaw Stephen R.
Carter Jeffery S.
Collins Paul W.
Docter Stephen H.
Graneto Matthew J.
G.d. Searle & Co.
Smart & Biggar
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