C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61P 31/12 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/04 (2006.01) C07D 409/04 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 417/14 (2006.01) C07D 491/04 (2006.01)
Patent
CA 2734486
The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and pro-drugs of said compounds, wherein wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
La présente invention porte sur des composés de Formule (I) : et sur des tautomères, isomères et esters desdits composés, et sur des sels, solvates et promédicaments pharmaceutiquement acceptables desdits composés, dans lesquels chacun parmi R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 et n sont choisis indépendamment et sont tels que définis présentement. L'invention porte également sur des compositions comprenant de tels composés. Les composés de l'invention sont efficaces en tant qu'inhibiteurs du VHC, et sont utiles, seuls ou conjointement avec d'autres agents thérapeutiques, dans le traitement ou la prévention de maladies ou de troubles tels que des infections virales et des troubles liés à des virus.
Ananthan Subramaniam
Arasappan Ashok
Bennett Frank
Clark Jeremy
Fowler Anita T.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
Southern Research Institute
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