Substituted pyridine derivatives useful in the treatment of...

Details Substituted pyridine derivatives useful in the treatment of... Substituted pyridine derivatives useful in the treatment of...

C - Chemistry, Metallurgy

07

D

C07D 213/81 (2006.01) A61K 31/4412 (2006.01) A61K 31/4433 (2006.01) C07D 213/83 (2006.01) C07D 213/86 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/02 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2516627

This invention relates to novel diaryl ureas of formula I wherein A is phenyl, naphthyl, mono- or bi-cyclic heteroaryl, or a group of the formula B is phenyl, naphthyl, or pyridyl, L is a bridging group Q is: (1) C(S)NR4R5; (2) C(O)NR7-NR4R5; (3) tetrazolyl; (4) imidazolyl; (5) imidazoline-2-yl; (6) 1,3,4- oxadiazoline-2-yl; (7) 1,3-thiazoline-2-yl; (8) 5-thioxo-4,5-dihydro-1,3,4- thiazoline-2-yl; (9) 5-oxo-4,5-dihydro-1,3,4-oxadiazoline-2-yl; or (10) a group of the formula and, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper- proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.

La présente invention concerne de nouvelles urées de diaryle, des compositions pharmaceutiques contenant de tels composés et l'utilisation de ces composés ou de ces compositions pour traiter des troubles d'hyperprolifération et d'angiogenèse, en tant qu'agent exclusif ou en combinaison avec des thérapies cytotoxiques.

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