Substituted pyridines, their preparation and pharmaceutical use

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 213/24 (2006.01) A61K 31/44 (2006.01) C07D 213/50 (2006.01) C07D 213/55 (2006.01)

Patent

CA 2134563

2134563 9323375 PCTABS00028 Compounds having general formula: (3) wherein each of R1 and R2 independently represents hydrogen or alkyl of 1 to 4 carbon atoms; A represents -O- or -CR4R5, where R4 and R5 are defined as for R1 or R2; R3 represents an adamantyl group; and Py represents a 3- or 4-pyridyl group, as free bases or their pharmaceutically acceptable salts are useful in treating androgen-dependent, especially prostatic, cancer.

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