Substituted pyrido (2 , 3-d) pyrimidine derivatives useful...

Details Substituted pyrido (2 , 3-d) pyrimidine derivatives useful... Substituted pyrido (2 , 3-d) pyrimidine derivatives useful...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2598465

This invention relates to a group of trisubstituted pyrido(2,3-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These derivatives are also useful in preventing or treating cardiovascular disorders, disorders of the central nervous system, TNF-.alpha. related disorders and cell proliferative disorders.

La présente invention concerne un groupe de dérivés trisubstitués de pyrido(2,3-d)pyrimidine, leurs sels pharmaceutiquement acceptables, des/leurs oxydes N, des solvates et énantiomères possédant des propriétés pharmaceutiques souhaitables inattendues, notamment en tant qu~agents immunosuppresseurs extrêmement actifs, et étant à ce titre utiles dans le traitement du rejet de greffe et/ou dans le traitement de certaines maladies inflammatoires. Ces dérivés sont également utiles dans la prévention ou le traitement des troubles cardiovasculaires, des troubles du système nerveux central, des troubles liées au TNF-.alpha. et des troubles associés à la prolifération cellulaire.

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