C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/4709 (2006.01) A61K 31/517 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2658462
The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula: (I); wherein A0-3 and R1-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
La présente invention concerne une nouvelle classe de composés qui est capable de moduler le récepteur c-kit et se révèle en conséquence utile pour le traitement de maladies médiées par le c-kit, incluant diverses maladies inflammatoires, fibrotiques et/ou médiées par les mastocytes, telles qu'une mastocytose. Les composés répondent à la Formule générale : (I), A0-3 et R1-6 étant définis dans ce document. L'invention concerne en outre des compositions pharmaceutiques, des procédés de traitement de maladies médiées par le c-kit, des intermédiaires et des procédés utiles pour la préparation des composés de l'invention.
Hu Essa
Human Jason Brooks
Kunz Roxanne
Tasker Andrew
White Ryan
Amgen Inc.
Gowling Lafleur Henderson Llp
LandOfFree
Substituted pyridone compounds and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Substituted pyridone compounds and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted pyridone compounds and methods of use will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1651465