Substituted pyridyl-dihydroxy-heptenoic acid and its salts

Details Substituted pyridyl-dihydroxy-heptenoic acid and its salts Substituted pyridyl-dihydroxy-heptenoic acid and its salts

C - Chemistry, Metallurgy

07

D

C07D 213/54 (2006.01) A61K 31/44 (2006.01) C07D 213/26 (2006.01) C07D 213/30 (2006.01) C07D 213/55 (2006.01) C07D 213/56 (2006.01)

Patent

CA 2057444

The substituted pyridyl-dihydroxy-heptenoic acid and its salts, if desired in an isomeric form, can be prepared by hydrolysing the appropriate racemic esters in the case of racemic products, or by reacting the racemic esters with enantiomeric amines in the case of the stereoisomerically homogeneous products, separating the diastereomeric amides and then hydrolysing these amides. The products have very good pharmacological properties. They can be employed as HMG-CoA reductase inhibitors for the treatment of hyperlipoproteinaemia and arteriosclerosis.

On peut préparer de l'acide pyridyl-dihydroxy-hepténoïque substitué, et ses sels, au besoin sous une forme isomérique particulière, par hydrolyse des esters racémiques appropriés dans le cas de produits racémiques ou par réaction des esters racémiques avec des amines énantiomériques dans le cas de produits stéréoisomériquement homogènes, par séparation des amides diastéréoisomériques et par hydrolyse de ces amides. Les produits se caractérisent par de très bonnes propriétés pharmacologiques. Ils peuvent être employés comme inhibiteurs de la HMG-CoA réductase pour le traitement de l'hyperlipoprotéinémie et de l'artériosclérose.

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