Substituted pyrimidin-2-ones and the salts thereof

Details Substituted pyrimidin-2-ones and the salts thereof Substituted pyrimidin-2-ones and the salts thereof

C - Chemistry, Metallurgy

07

D

260/255

C07D 239/36 (2006.01) C07D 239/38 (2006.01)

Patent

CA 1180710

Abstract Substituted pyrimidin-2-ones and the salts thereof Compounds of the general formula:- Image I (wherein X represents a halogen atom or a trifluoromethyl group; R1 and R2 independently represent a hydrogen atom or a lower alkyl group; Z is -O-, -S-, -SO-, -SO2- or the group -NR4- wherein R4 is as defined for R hereinafter or represents the group COR5 in which R5 represents a hydrogen atom or an optionally substituted aryl, heterocyclic, aralkyl, lower alkyl or lower alkoxy group; R represents a C6-10 carbocyclic aromatic group or a heterocyclic group containing a 5-9 membered unsaturated or aromatic heterocyclic ring which ring contains one or more heteroatoms selected from O, N and S and optionally carries a fused ring which carbocyclic or heterocyclic group may carry one or more C1-4 alkyl or phenyl groups, said groups being optionally substituted; or, where Z represents the group ?NR4, the group -ZR may represent a heterocyclic ring optionally carrying a fused ring and/or optionally substituted as defined for R; and R3 represents a hydrogen atom or a lower alkyl, lower alkenyl, lower alkynyl, lower alkanoyl, lower alkenoyl, C7-16 aralkyl or C6-10 aryl group or a 5-9 membered unsaturated or aromatic heterocyclic ring); and, where acid or basic groups are present, the salts thereof; are useful in combating abnormal cell proliferation. The compounds of the invention are prepared by inter alia alkylation, ring closure and oxidation.

393785

Affiliated with

Also associated with

Rating

Substituted pyrimidin-2-ones and the salts thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Substituted pyrimidin-2-ones and the salts thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Substituted pyrimidin-2-ones and the salts thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1199275