Substituted pyrimidin-5-carboxamides 281

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 239/28 (2006.01) A61K 31/506 (2006.01) A61P 3/10 (2006.01) C07D 239/38 (2006.01) C07D 239/42 (2006.01) C07D 239/47 (2006.01) C07D 239/48 (2006.01) C07D 239/557 (2006.01) C07D 239/58 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2719936

A compound of formula (I) and pharmaceutically-acceptable salts thereof wherein the variable groups are defined within; their use in the inhibition of 11.beta.HSD1, processes for making them and pharmaceutical compositions comprising them are also described.

L'invention porte sur un composé de formule (I) et sur des sels pharmaceutiquement acceptables de celui-ci, dans laquelle formule les groupes variables sont tels que définis dans la description. L'invention porte également sur leur utilisation dans l'inhibition de 11ßHSD1, sur des procédés permettant de les fabriquer et sur des compositions pharmaceutiques les comprenant.

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