Substituted pyrimidine derivatives useful in the treatment...

Details Substituted pyrimidine derivatives useful in the treatment... Substituted pyrimidine derivatives useful in the treatment...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/506 (2006.01)

Patent

CA 2634084

Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A= pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.

La présente invention concerne des dérivés substitués de la pyrimidine de formule (I), dans laquelle A = pyrimidine, leurs sels, métabolites, promédicaments et formes diastéréoisomères (aussi bien des stéréoisomères isolés que des mélanges de stéréoisomères), des compositions pharmaceutiques contenant de tels composés et l'utilisation de ces composés ou compositions pour le traitement de l'hyper-prolifération et les dérèglements de l'angiogenèse, en tant que seul agent ou en combinaison avec d'autres matières actives, par exemple des traitements cytotoxiques.

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