Substituted pyrimidines

Details Substituted pyrimidines Substituted pyrimidines

C - Chemistry, Metallurgy

07

D

260/262.5

C07D 239/49 (2006.01) C07D 215/12 (2006.01) C07D 215/40 (2006.01) C07D 239/48 (2006.01) C07D 311/64 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01)

Patent

CA 1186310

Abstract Compounds of the formula (1): Image (I) or a salt, N-oxide or acyl derivative thereof, wherein (?) is a six membered ring optionally containing a hetero atom double bonds, both the phenyl ring and the (?) being optionally susbstituted except that when (?) does not contain a hetero atom either or both the phenyl ring or (?) must be substituted other than solely by a hydroxy group at the 4-position of the pnenyl ring, and that there are no substituents attached to the atom of (?) adjacent to the 6-position of the phenyl ring are useful in the treatment of bacterial infections A process for preparing these compounds and novel chemical intermediates used in their preparation are disclosed as is the first medical use of the compounds of the formula (I) and pharmaceutical compositions containing them.

389807

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