Substituted pyrimidinone and pyridinone compounds and their use

Details Substituted pyrimidinone and pyridinone compounds and their use Substituted pyrimidinone and pyridinone compounds and their use

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 401/14 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 405/04 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2274093

Selected novel substituted pyrimidinone and pyridone compounds are effective for prophylaxis and treatment of diseases, such as TNF-.alpha., IL-.beta., IL-6 and/or IL-8 mediated diseases, and other maladies, such as pain and diabetes. The invention encompasses novel compounds of the following general formula: (see formula I) analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for phrophylaxis and treatment of diseases and other maladies or conditions involving inflammation, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

Cette invention concerne de nouveaux composés substitués sélectionnés, à base de pyrimidone et de pyridone, qui s'avèrent efficaces s'agissant de la prophylaxie et du traitement de maladies, telles que les maladies induites par le TNF- alpha , IL-1 beta , IL-6 et/ou IL-8, et d'autres maladies, telles que le diabète, ou de symptômes du type douleur. L'invention se rapporte à de nouveaux composés, à des analogues, à des promédicaments et à des sels pharmaceutiquement acceptables de ces composés, à des compositions pharmaceutiques et à des procédés de prophylaxie et de traitement de maladies et autres symptômes ou troubles liés à une inflammation, à une douleur, au diabète ou analogue. La présente invention se rapporte également à des procédés de fabrication de tels composés ainsi qu'à des intermédiaires utiles à ces procédés.

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