Substituted pyrimidinones and pyrimidinthiones as crf...

Details Substituted pyrimidinones and pyrimidinthiones as crf... Substituted pyrimidinones and pyrimidinthiones as crf...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/513 (2006.01) A61P 25/00 (2006.01) C07D 401/14 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2522803

This invention relates to substituted pyrimidinone and pyrimidithione derivatives that bind with high affifnity to CRF1 receptors, including human CRF1 receptors. This invention also relates to methods of using the compounds of the invention to treat a disorder or condition, the treatment of which can be effected or facilitated by antagonizing a CRF receptor, such as CNS disorders or diseases, particularly anxiety disorders, and depression and stress related disorders.

La présente invention concerne des dérives substitués de pyrimidinone et de pyrimidinthione se liant avec une haute affinité aux récepteurs du CRF¿1?, notamment les récepteurs du CRF¿1? humain. L'invention concerne également des méthodes pour utiliser lesdits composés en vue de traiter un trouble ou un état pathologique dont le traitement peut être effectué ou facilité par l'opposition aux effets du récepteur de la corticolibérine, par exemple des troubles ou des maladies du SNC, en particulier les troubles liés à l'anxiété, à la dépression et au stress.

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